November 1, 2001American Journal of Respiratory Cell and Molecular Biology

Bleomycin Upregulates Gene Expression of Angiotensin-Converting Enzyme via Mitogen-Activated Protein Kinase and Early Growth Response 1 Transcription Factor

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Population

Primary bovine pulmonary artery endothelial cells

Design

Preclinical

Authors

RDRegina M. DayUniformed Services University of the Health Sciences YYYongzhen YangEnvironmental Protection Engineering (Greece)YSYuichiro SuzukiHirosaki University

Discussion

Member takes

Implication

Identifies a pathway in experimental fibrosis models; leaves open any therapeutic relevance in human lung disease.

Structured PICO

Population

Primary bovine pulmonary artery endothelial cells

Intervention

Bleomycin (0.1 to 1.0 microg/ml)

Outcome

ACE enzymatic activity and ACE mRNA expressionsurrogate

This study provides the first evidence that bleomycin activates ACE gene expression through the MAPK pathway and Egr-1, offering a potential mechanistic link between bleomycin and pulmonary fibrosis.

Cite This Study

Day et al. (2001) studied this question.

synapsesocial.com/papers/6a71a33ae5469ee92be211b2 https://doi.org/10.1165/ajrcmb.25.5.4521

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Bleomycin Upregulates Gene Expression of Angiotensin-Converting Enzyme via Mitogen-Activated Protein Kinase and Early Growth Response 1 Transcription Factor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Bleomycin Upregulates Gene Expression of Angiotensin-Converting Enzyme via Mitogen-Activated Protein Kinase and Early Growth Response 1 Transcription Factor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider