Why the study?
Does ACE2 treatment improve pulmonary vascular remodeling and hemodynamics in a murine model of bleomycin-induced pulmonary hypertension?
Population
Adult FVB/N mice with bleomycin-induced pulmonary fibrosis (0.018 U/g bleomycin 2x/week for 4 weeks)
Comparison
ACE2 administered via osmotic pump for 2 weeks… vs Vehicle administered via osmotic pump
Design
Preclinical
Follow-up
5 weeks following the first bleomycin injection
Authors
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May support ACE2 investigation in group 3 PH; hypothesis-generating from murine data and leaves clinical translation open.
Does ACE2 treatment improve pulmonary vascular remodeling and hemodynamics in a murine model of bleomycin-induced pulmonary hypertension?
ACE2 treatment attenuates pulmonary vascular remodeling and increases SOD2 expression in a murine model of bleomycin-induced pulmonary hypertension, suggesting potential therapeutic benefit for group 3 PH.
Rathinasabapathy et al. (2018) studied this question.
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