Weighing in on the role of brown adipose tissue for treatment of obesity

Figures

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  FIGURE 1. An overview of molecules that activate brown adipose tissue (BAT) or browning of white adipose tissue (WAT) and evidence to support in biological model of rodents or humans. *Note: the evidence summarized in each section represents data provided from both in vitro and in vivo models in rodents and humans. Abbreviations: Angiotensin type 2 receptor (AT2R), Beta-adrenergic receptor (βADR), Cold-induced thermogenesis (CIT), Diet induced obesity (DIO), Energy expenditure (EE), Fibroblast growth factor 21 (FGF21), Fludeoxyglucose (18F-FDG), Guanosine diphosphate (GDP), High fat diet (HFD), Non-esterified fatty acid (NEFA), Onion peel extract (OPE), Peroxisome proliferator-activated receptor γ (PPARγ), Respiratory exchange ratio (RER), Sympathetic nervous system (SNS), Withania somnifera extract (WSE), Uncoupling Protein 1 (Ucp1). Image created in Biorender.

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  FIGURE 2. An overview of hormones that inhibit brown adipose tissue (BAT) or browning of white adipose tissue (WAT) in rodents and humans. *Note: the evidence summarized in each section represents data provided from both in vitro and in vivo models in rodents and humans. Abbreviations: Body mass index (BMI), Cold-induced thermogenesis (CIT), Energy expenditure (EE), Mineralocorticoid receptor (MR), Mineralocorticoid receptor antagonist (MRA). Image created in Biorender.