July 15, 2003Arteriosclerosis Thrombosis and Vascular Biology
Platelet Activation Induces Cell-Surface Immunoreactive Tissue Factor Expression, Which Is Modulated Differently by Antiplatelet Drugs
Why the study?
Do platelet agonists and antiplatelet drugs modulate membrane-associated immunoreactive tissue factor expression in platelets from healthy subjects?
Population
Platelets (whole blood, platelet-rich plasma, and washed platelets) isolated from healthy subjects
Comparison
Platelet agonists and antiplatelet drugs vs Unstimulated platelets
Design
Preclinical
Authors
Discussion
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Member takes
Implication
May implicate platelet tissue factor in thrombosis; leaves open clinical relevance of differential antiplatelet effects.
Structured PICO
Do platelet agonists and antiplatelet drugs modulate membrane-associated immunoreactive tissue factor expression in platelets from healthy subjects?
P
Population
Platelets (whole blood, platelet-rich plasma, and washed platelets) isolated from healthy subjects
I
Intervention
Platelet agonists (ADP, thrombin receptor-activating peptide, epinephrine) and antiplatelet drugs (iloprost, aspirin, glycoprotein IIb/IIIa antagonists)
C
Comparator
Unstimulated platelets
O
Outcome
Membrane-associated immunoreactive tissue factor (irTF) expressionsurrogate
Platelet agonists induce tissue factor expression on platelets, a process that is differentially modulated by antiplatelet drugs, suggesting a novel role for platelets in coagulation-mediated thrombus formation.
Cite This Study
Camera et al. (2003) studied this question.