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November 1, 2020European Heart Journal

The Odds Ratio for the composite clinical end point in patients with moderate to severe CAC was 3.4 (p<0.01), similar to the OR predicted by the FRS (3.1; p<0.01).

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Why the study?

Evidence links non-gated CT-detected coronary artery calcification to cardiovascular disease, but the utility of incidental CAC on non-triggered HRCT thorax scans compared with the Framingham risk score needed evaluation.

Does incidental coronary artery calcification on non-gated HRCT thorax predict cardiac events as well as the Framingham Risk Score in patients undergoing respiratory CT scans?

Population

300 patients undergoing HRCT thorax for lung cancer screening or interstitial lung disease follow-up

Comparison

Incidental CAC on non-triggered HRCT vs Framingham risk score

Design

Retrospective single-trust cohort study

Follow-up

Median duration of follow up of 1.6 years

Authors

SSSushant SalujaHCHussain ContractorMDM Daniells

Discussion

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Member takes

Overview

Incidental CAC on non-gated HRCT may inform CVD risk during lung screening; leaves open prospective validation before clinical adoption.

Structured PICO

Does incidental coronary artery calcification on non-gated HRCT thorax predict cardiac events as well as the Framingham Risk Score in patients undergoing respiratory CT scans?

P
Population
300 patients undergoing non-triggered high resolution CT (HRCT) thorax for lung cancer screening or follow-up for interstitial lung disease.
I
Intervention
Coronary artery calcification (CAC) score calculated using the Agatston method from non-gated HRCT thorax scans.
C
Comparator
Framingham Risk Score (FRS).
O
Outcome
Composite of all-cause mortality and cardiac events (non-fatal myocardial infarction, coronary revascularization, new atrial fibrillation or heart failure episode requiring hospitalization).composite

Incidental coronary artery calcification detected on non-gated HRCT thorax scans strongly predicts cardiac events, showing good concordance with the Framingham Risk Score.

Limitations

  • retrospective study
  • single trust
  • small patient cohort

Cite This Study

Saluja et al. (2020) studied this question.

synapsesocial.com/papers/6a71a4445671bbf00bc2ee4chttps://doi.org/10.1093/ehjci/ehaa946.0172
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Correlation between coronary artery calcification by non-cardiac CT and Framingham score in young patients2018 · 11 citations
  2. 2Incidentally identified coronary artery calcium on non-contrast CT scan of the chest predicts major adverse cardiac events among hospital inpatients2021 · 23 citations
  3. 3Coronary Artery Calcification on Non-Cardiac Gated CT Thorax Scans: A Single Tertiary Centre Retrospective Observational Study2025
  4. 4Coronary Artery Calcification on Non-Cardiac Gated CT Thorax Scans: A Single Tertiary Centre Retrospective Observational Study2025
  5. 5Prevalence and clinical implications of coronary artery calcium scoring on non-gated thoracic computed tomography: a systematic review and meta-analysis2023 · 42 citations