November 24, 2004Journal of VirologyOpen Access

Identification of a Naturally Processed Cytotoxic CD8 T-Cell Epitope of Coxsackievirus B4, Presented by HLA-A2.1 and Located in the PEVKEK Region of the P2C Nonstructural Protein

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Structured PICO

Population

In vitro/ex vivo model using peripheral blood CD8 T cells and antigen-presenting cells to study Coxsackievirus B4 (CVB4) epitopes

Intervention

P2C(1137-1145) peptide epitope from CVB4

Comparator

GAD(65) peptide homologue

Outcome

Epitope recognition by effector memory CD8 T cells (IFN-gamma production) and cytotoxicitysurrogate

Identifies the first CD8 T-cell epitope of Coxsackievirus B4, which may help in studying CVB4-associated inflammatory and autoimmune diseases.

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This non-cross-reactive epitope supports targeted CVB4 T-cell studies in models; hypothesis-generating and should not yet change practice.

Varela‐Calviño et al. (2004) studied this question.

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This non-cross-reactive epitope supports targeted CVB4 T-cell studies in models; hypothesis-generating and should not yet change practice.