June 20, 2018PLoS ONEOpen Access

In silico and ex vivo approaches indicate immune pressure on capsid and non-capsid regions of coxsackie B viruses in the human system

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Structured PICO

Population

HLA-A*02:01 positive non-diabetic donors (n=18) and HLA-A*02:01 patients with recent-onset type 1 diabetes (n=19)

Intervention

Ex vivo stimulation of PBMCs with pools of synthetic peptides derived from CBV capsid and non-capsid proteins

Comparator

Diluent alone and viral peptide mix CEF control

Outcome

IFNγ responses measured by ELISpotsurrogate

Anti-CBV CD8 T cell immunity targets both capsid and non-capsid regions, which has implications for CBV vaccination strategies.

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Similar anti-CBV CD8 responses in recent T1D and controls; leaves open role in pathogenesis and CBV vaccine epitope targeting.

Kundu et al. (2018) studied this question.

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