Preoperative use of PDE III inhibitors to improve pulmonary hypertension may help determine surgical indications for aortic valve replacement in high-risk patients with severe aortic stenosis.
May support preoperative PDE III inhibition to enable AVR in select severe AS with PH; single case leaves open broader efficacy and safety.
肺高血圧合併大動脈弁疾患の予後は不良で，外科治療の成績も満足いくものではなく，手術適応に一定の見解が得られていない．透析中の 58 歳男性が大動脈弁狭窄症による急性心不全と診断され，術前検査で高度肺高血圧を認めた．術前にpde Iii 阻害薬を投与し，肺高血圧症の改善をみた後に大動脈弁置換術を行なった．本症例のように術前に Pde Iii 阻害薬で肺高血圧の改善を認めたことは手術適応を決める 1 つの方法になると考えられた．
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Sezai et al. (2011) studied this question.
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