November 4, 2013Toxicological SciencesOpen Access

Test of the Usefulness of a Paradigm to Identify Potential Cardiovascular Liabilities of Four Test Articles With Varying Pharmacological Properties in Anesthetized Guinea Pigs

View Full Paper

Ask AI

Bookmark

Population

29 male guinea pigs

Comparison

Intravenous infusions of vehicle and two… vs Baseline measurement and vehicle infusion

Design

Preclinical

Follow-up

10 minutes per infusion

Authors

AKAnusak KijtawornratChulalongkorn University YUYukie UeyamaNationwide Children's Hospital CRCarlos del RíoRush University Medical Center

Discussion

Member takes

Implication

Does not yet alter clinical practice; extends validation of anesthetized guinea pig models for integrated preclinical cardiac safety screening.

Structured PICO

Population

29 male guinea pigs

Intervention

Intravenous infusions of vehicle and two escalating concentrations of either chromanol 293B (n = 8), milrinone (n = 6), metoprolol (n = 7), or nicorandil (n = 8) for 10 minutes each

Comparator

Baseline measurement and vehicle infusion

Outcome

Direct and indirect indices of left ventricular function (including slope of preload-recruitable stroke work, contractility index, and static myocardial compliance), electrocardiograms, and systemic arterial pressuresurrogate

An anesthetized guinea pig preparation is a feasible and accurate model for preclinical assessment of simultaneous drug-induced electrocardiographic and hemodynamic changes.

Cite This Study

Kijtawornrat et al. (2013) studied this question.

synapsesocial.com/papers/6a71a76c35aa2c282ce2dbdd https://doi.org/10.1093/toxsci/kft244

View Full Paper

Ask AI

Bookmark

Implication

Does not yet alter clinical practice; extends validation of anesthetized guinea pig models for integrated preclinical cardiac safety screening.

Test of the Usefulness of a Paradigm to Identify Potential Cardiovascular Liabilities of Four Test Articles With Varying Pharmacological Properties in Anesthetized Guinea Pigs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Test of the Usefulness of a Paradigm to Identify Potential Cardiovascular Liabilities of Four Test Articles With Varying Pharmacological Properties in Anesthetized Guinea Pigs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider