Why the study?
Does single oral administration of reference compounds induce QTc prolongation in conscious freely moving guinea pigs?
Population
Male Dunkin Hartley guinea pigs with intraperitoneally implanted telemetry transmitters
Comparison
Single oral administration of reference compounds vs Vehicle or negative reference (enalapril)
Design
Preclinical
Follow-up
from two days up to eight months
Authors
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Supports guinea pig telemetry as a QTc screening model; leaves open human translation.
Does single oral administration of reference compounds induce QTc prolongation in conscious freely moving guinea pigs?
Conscious freely moving guinea pigs with telemetry implants serve as a suitable and cost-effective preclinical model for screening drug-induced QT interval prolongation.
Hess et al. (2007) studied this question.
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