Why the study?
Does the administration of QT-lengthening test articles and anesthesia affect the QT and RR interval relationship in conscious and anesthetized guinea pigs?
Population
22 guinea pigs
Comparison
Administration of zatebradine to slow heart… vs Vehicle and non-QTc lengthening test articles
Design
Preclinical
Authors
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Anesthesia alters QT assessment in guinea pigs; leaves open whether conscious or anesthetized models better predict clinical torsadogenicity.
Does the administration of QT-lengthening test articles and anesthesia affect the QT and RR interval relationship in conscious and anesthetized guinea pigs?
This methodology in conscious and anesthetized guinea pigs may be useful for exploring torsadogenic effects of novel pharmacological entities.
Robert L. Hamlin (2003) studied this question.
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