Key result
Van der Water formula provides the most consistent QT interval correction in conscious guinea pigs.
Why the study?
Healthy conscious guinea pigs have not been fully characterized for normal electrocardiographic patterns and optimal QT correction formula in a controlled laboratory setting.
Observational (n=50)
Effect estimate: r=98 (95% CI 185.7-195.2)
p-value: p=<0.05
The Van der Water formula is the most appropriate for QT interval correction in conscious guinea pigs, establishing reference electrocardiographic values for the species.
Guinea pig ECG model yields normal patterns and QT formula; leaves open translation to human electrophysiology.
The purpose of this study is to evaluate healthy conscious guinea pigs as a model for electrophysiology assessment and to describe normal electrocardiographic patterns in controlled laboratory environment, establishing the best QT formula for this method. Electrocardiographic recordings of fifty adult conscious guinea pigs were obtained using a computerized electrocardiography. The electrocardiographic measurements of three different tracings were analyzed. The results obtained established normal mean and range values for the parameters: heart rate, waves and intervals of P-QRS-T deflections, as well as the mean cardiac axis. Groups were separated by body weight: group 1 gathered animals with 500-699g and group 2 with animals 700-900g. No differences were found when measurements were compared between groups, showing no significant difference between weight/body sizes to the electrocardiographic parameters (P<0.05). The mean corrected QT values (QTc) obtained using diverse formulae were significantly different (P<0.05), were the most consistent was Van der Water (QTcV). QTcV values were strongly correlated (r=98) and 95% confidence interval 185.7 to 195.2ms.Considering its simplicity and reliability, the QTcV was deemed the most appropriate to be used for the correction of QT interval in conscious guinea pigs.The results of this study also suggest that the values found can be used as reference for the species.
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Botelho et al. (2016) conducted an observational in Healthy (n=50). Van der Water formula (QTcV) vs. Other QT correction formulae was evaluated on Corrected QT values (QTc) (r=98, 95% CI 185.7-195.2, p=<0.05). The Van der Water formula (QTcV) was the most consistent method for QT interval correction in conscious guinea pigs (mean QTcV 95% CI 185.7-195.2 ms).
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