Why the study?
Does the anaesthetized guinea-pig model reliably detect drug-induced QT prolongation for preliminary screening of torsadogenicity?
Population
Guinea-pigs under pentobarbital anaesthesia
Comparison
Intravenous administration of seven known… vs Comparison between torsadogenic and…
Design
Preclinical
Authors
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Supports guinea-pig model for torsadogenic screening; leaves open human translation.
Does the anaesthetized guinea-pig model reliably detect drug-induced QT prolongation for preliminary screening of torsadogenicity?
The anaesthetized guinea-pig model is a reliable, rapid, and low-cost method for preliminary screening of drug-induced QT prolongation and torsadogenic risk.
Testai et al. (2004) studied this question.
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