January 1, 2005Journal of Pharmacological SciencesOpen Access

QT PRODACT: Usability of Miniature Pigs in Safety Pharmacology Studies: Assessment for Drug-Induced QT Interval Prolongation

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Why the study?

Can miniature pigs be used to predict drug-induced QT interval prolongation in humans?

Population

Conscious and unrestricted miniature pigs

Comparison

Haloperidol, dl-propranolol, and dl-sotalol vs Vehicle average baseline values

Design

Preclinical

Authors

MKMayumi KanoNihon University TTTohru ToyoshiJapan Medical Association SISakae IwasakiKochi Medical School Hospital

Discussion

Member takes

Implication

Supports miniature pigs for QT safety screening; leaves open human translation before clinical use.

Structured PICO

Can miniature pigs be used to predict drug-induced QT interval prolongation in humans?

Population

Conscious and unrestricted miniature pigs

Intervention

Haloperidol (3 and 10 mg/kg, p.o.), dl-propranolol (3, 10, and 30 mg/kg, p.o.), and dl-sotalol (10 mg/kg, p.o.)

Comparator

Vehicle average baseline values

Outcome

QTcF interval (Fridericia's formula) prolongationsurrogate

Miniature pigs are a useful animal model for predicting drug-induced QT interval prolongation in safety pharmacology studies.

Cite This Study

Kano et al. (2005) studied this question.

synapsesocial.com/papers/6a708927f44fa9f079de333b https://doi.org/10.1254/jphs.qt-c13

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QT PRODACT: Usability of Miniature Pigs in Safety Pharmacology Studies: Assessment for Drug-Induced QT Interval Prolongation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

QT PRODACT: Usability of Miniature Pigs in Safety Pharmacology Studies: Assessment for Drug-Induced QT Interval Prolongation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider