What question did this study set out to answer?

To measure blood flow and vascular resistance in coronary vein grafts under resting conditions and following vasodilator administration.

November 1, 1971Archives of Surgery

Coronary Hemodynamics Following Aorta-Coronary Bypass Graft

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Why the study?

Does papaverine hydrochloride administration into the graft improve coronary vein graft flow and resistance in patients undergoing aorta-coronary bypass graft?

Population

21 patients (31 grafts) undergoing aorta-coronary bypass graft

Comparison

Papaverine hydrochloride administered into the… vs Baseline (before administration of papaverine)

Design

Case_series

Authors

JMJohn M. MoranRutgers, The State University of New Jersey

Discussion

Member takes

Implication

May support papaverine in bypass grafts; hypothesis-generating for patency, should not change practice.

Key Points

To measure blood flow and vascular resistance in coronary vein grafts under resting conditions and following vasodilator administration.
Measured coronary vein graft flow and aortic or intragraft pressure across 31 grafts in 21 patients under stable hemodynamic conditions.
Calculated vascular resistance in peripheral resistance units before and after administering 10 mg of intragraft papaverine hydrochloride.
Baseline flow was higher in left-side grafts (73 ± 23 ml/min) than right-side grafts (53 ± 25 ml/min), with lower resistance on the left (1.2 ± 0.4 pru vs. 2.6 ± 1.6 pru).
Papaverine administration increased average blood flow by 93% in left grafts and 110% in right grafts, with concurrent reductions in resistance across both sides.
Three of four grafts that became occluded exhibited baseline flow rates under 30 ml/min and high resistance values between 2.5 and 8.0 pru.

Structured PICO

Does papaverine hydrochloride administration into the graft improve coronary vein graft flow and resistance in patients undergoing aorta-coronary bypass graft?

Population

21 patients (31 grafts) undergoing aorta-coronary bypass graft

Intervention

Papaverine hydrochloride (10 mg) administered into the graft

Comparator

Baseline (before administration of papaverine)

Outcome

Coronary vein graft flow and resistance to flowsurrogate

Intragraft administration of papaverine significantly increases coronary vein graft flow and reduces resistance, while low baseline flow and high resistance may predict graft occlusion.

Cite This Study

John M. Moran (1971) studied this question.

synapsesocial.com/papers/6a71a83dac440176ef2a4646 https://doi.org/10.1001/archsurg.1971.01350110037005

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Coronary Hemodynamics Following Aorta-Coronary Bypass Graft

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Coronary Hemodynamics Following Aorta-Coronary Bypass Graft

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

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