Why the study?
Does long QT syndrome status moderate the association between stressful life events and depressive symptoms in long QT syndrome mutation carriers?
Does long QT syndrome status moderate the association between stressful life events and depressive symptoms in long QT syndrome mutation carriers?
Symptomatic long QT syndrome patients are significantly more sensitive to the depressive effects of stressful life events compared to asymptomatic mutation carriers.
May warrant targeted depression screening in symptomatic long QT syndrome after stress; hypothesis-generating for symptom status as moderator.
We examined whether long QT syndrome status moderates the association between stressful life events and depressive symptoms. Participants were 562 (n= 246 symptomatic) long QT syndrome mutation carriers. Depressive symptoms were measured with a modified version of the Beck's Depression Inventory. There was an interaction between long QT syndrome status and stressful life events on depressive symptoms. In the symptomatic long QT syndrome patients, stressful life events were associated with depressive symptoms (B= 0.24, p< 0.001). In the asymptomatic long QT syndrome mutation carriers, this association was 62.5 percent weaker (B= 0.09, p= 0.057). Compared to asymptomatic long QT syndrome mutation carriers, symptomatic long QT syndrome patients are more sensitive to the depressive effects of stressful life events.
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Hintsa et al. (2014) studied this question.
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