Population
Patients with Brugada syndrome, suspected mutation carriers, or individuals susceptible to drug-induced…
Design
Review
Authors
Discussion
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Member takes
Implication
A wide range of non-antiarrhythmic drugs can induce a Brugada ECG pattern, highlighting the importance of recognizing drug-induced Brugada syndrome in clinical practice.
Key Points
- To review reported cases and clinical evidence regarding drug-induced Brugada syndrome and examine the mechanisms underlying acquired Brugada-type electrocardiogram patterns.
- Narrative review of published clinical literature and case reports documenting drug-induced Brugada ECG patterns and associated pharmacological agents.
- Multiple classes of non-cardiac drugs—including tricyclic antidepressants, fluoxetine, lithium, trifluoperazine, antihistamines, and cocaine—can induce diagnostic type 1 Brugada ECG patterns.
- Acquired Brugada patterns likely result from individual susceptibility and latent ion channel dysfunction unmasked by pharmacological stress, paralleling drug-induced long QT syndrome.
Structured PICO
P
Population
Patients with Brugada syndrome, suspected mutation carriers, or individuals susceptible to drug-induced Brugada ECG patterns
I
Intervention
Pharmacological agents including sodium channel blockers (ajmaline, flecainide, pilsicainide) and non-class I anti-arrhythmic agents (tricyclic antidepressants, fluoxetine, lithium, trifluoperazine, antihistamines, cocaine)
O
Outcome
Drug-induced Brugada ECG pattern (type 1 ECG pattern)surrogate
A wide range of non-antiarrhythmic drugs can induce a Brugada ECG pattern, highlighting the importance of recognizing drug-induced Brugada syndrome in clinical practice.
Cite This Study
Yap et al. (2009) studied this question.