Key result
Noncardiac agents, including psychotropic and anesthetic drugs, can unmask a genetic predisposition to Brugada syndrome and induce electrocardiogram patterns predisposing to fatal arrhythmias.
Why the study?
Do noncardiac agents induce Brugada syndrome in genetically predisposed patients?
Do noncardiac agents induce Brugada syndrome in genetically predisposed patients?
Noncardiac agents, such as psychotropic and anesthetic drugs, can unmask Brugada syndrome in genetically predisposed individuals, highlighting the need for careful prescribing and drug safety monitoring.
Drug-induced Brugada syndrome (BrS) represents a great challenge for the prescribing clinicians as well as for those involved in the development of novel pharmaceuticals and in the regulatory bodies responsible with monitoring drug safety. Apart from well-known cardiac agents (mainly Class I antiarrhythmics), an increasing number of noncardiac agents, including psychotropic and anesthetic drugs, have been shown to induce the characteristic Brugada electrocardiogram pattern predisposing to fatal ventricular arrhythmias. Up to now, both repolarization and depolarization abnormalities are thought to be related to the development of ventricular fibrillation in BrS patients. This review highlights the mechanisms and the noncardiac medical agents that unmask a genetic predisposition to BrS.
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Letsas et al. (2013) conducted a review in Drug-induced Brugada syndrome. Noncardiac agents (including psychotropic and anesthetic drugs) was evaluated on Development of Brugada electrocardiogram pattern and ventricular arrhythmias. Noncardiac agents, including psychotropic and anesthetic drugs, can unmask a genetic predisposition to Brugada syndrome and induce electrocardiogram patterns predisposing to fatal arrhythmias.
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