Why the study?
Novel techniques targeting angiotensinogen manipulation have enabled deeper investigation into the relationship between angiotensinogen and cardiovascular diseases.
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Design
Brief review
This review highlights the emerging role and mechanisms of angiotensinogen in cardiovascular diseases, including heart failure, hypertension, and atherosclerosis.
Angiotensinogen (AGT) is the unique precursor of all angiotensin peptides. Many of the basic understandings of AGT in cardiovascular diseases have come from research efforts to define its effects on blood pressure regulation. The development of novel techniques targeting AGT manipulation such as genetic animal models, adeno-associated viral approaches, and antisense oligonucleotides made it possible to deeply investigate the relationship between AGT and cardiovascular diseases. In this brief review, we provide contemporary insights into the emerging role of AGT in cardiovascular diseases. In light of the recent progress, we emphasize some newly recognized features and mechanisms of AGT in heart failure, hypertension, atherosclerosis, and cardiovascular risk factors.
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Xu et al. (2020) studied this question.
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