Why the study?
Does prenatal nicotine exposure alter synaptic inputs to cardioinhibitory vagal neurons during hypoxia in rats?
Population
In vitro rat brainstem slice preparation containing fluorescently labeled preganglionic cardioinhibitory…
Comparison
Prenatal nicotine exposure vs No prenatal nicotine exposure (implied control)
Design
Preclinical
Authors
Loading...
Hypothesis-generating for SIDS bradycardia mechanisms; leaves open translation to human infants.
Does prenatal nicotine exposure alter synaptic inputs to cardioinhibitory vagal neurons during hypoxia in rats?
Prenatal nicotine exposure alters the GABAergic response to hypoxia in rat brainstem cardioinhibitory vagal neurons, providing a potential neurochemical mechanism for exaggerated bradycardia implicated in Sudden Infant Death Syndrome (SIDS).
Neff et al. (2004) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: