Why the study?
Does prenatal to early postnatal nicotine exposure impair central chemoreception and modify breathing patterns in mouse neonates?
Population
CF1 pregnant mice (5-7 d) and their neonates
Comparison
Nicotine bitartrate (60 mg Kg day) delivered via… vs Saline solutions delivered via osmotic minipumps
Design
Preclinical
Follow-up
Up to postnatal day 8
Authors
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May link maternal smoking to SIDS via impaired neonatal chemoreception; hypothesis-generating and requires human confirmation before any clinical implications.
Does prenatal to early postnatal nicotine exposure impair central chemoreception and modify breathing patterns in mouse neonates?
Prenatal and early postnatal nicotine exposure impairs central chemoreception and respiratory rhythm in neonatal mice, providing a potential mechanistic link between maternal smoking and sudden infant death syndrome.
Eugenı́n et al. (2008) studied this question.
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