Population
Myosin subfragment 2 (putative hinge region in the myosin rod)
Comparison
Amino acid sequence determination and stability… vs Other portions of the rod and tropomyosin
Design
Preclinical
Authors
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Reduced hinge stability may alter myosin mechanics in cardiomyocytes; leaves open its role in human cardiac disease.
The determined amino acid sequence of the myosin subfragment 2 hinge region suggests reduced structural stability due to fewer hydrophobic interactions and more charged residues in the core.
Lu et al. (1985) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: