March 1, 2008Annals of the New York Academy of Sciences
Neonatal and Adult Cardiovascular Pathophysiological Remodeling and Repair
Population
Mice models and isolated/cultured embryonic, neonatal, and adult wild-type and periostin-null nonmyocyte…
Comparison
Targeted gene deletion of periostin, or forced… vs Wild-type or untreated nonmyocyte populations
Design
Preclinical
Authors
Discussion
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Overview
May warrant investigation as antifibrotic target; leaves open translation from animal models to clinical heart disease.
Structured PICO
P
Population
Mice models (single-cell engraftment) and isolated/cultured embryonic, neonatal, and adult wild-type and periostin-null nonmyocyte populations
I
Intervention
Targeted gene deletion of periostin, or forced expression/culturing with periostin
C
Comparator
Wild-type or untreated nonmyocyte populations
O
Outcome
Differentiation of progenitor cells, collagen fibrogenesis, and biomechanical properties of the myocardiumsurrogate
Periostin is a profibrogenic matricellular protein essential for promoting collagen fibrogenesis and maintaining the biomechanical properties of the adult myocardium.
Cite This Study
Norris et al. (2008) studied this question.