Key result
Periostin, regulated by TGFbeta-3, promotes mesenchymal-to-fibroblast differentiation and collagen I production in chick atrioventricular valve maturation while blocking myocyte differentiation.
Population
Chick atrioventricular mesenchyme and valve precursor cells
Design
Preclinical
Authors
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Hypothesis-generating for human valve maturation; requires mammalian validation before any translational consideration.
Periostin functions as a crucial mediator of chick AV valve maturation by promoting mesenchymal-to-fibroblast differentiation and blocking myocyte differentiation.
Norris et al. (2009) studied Valve remodeling and differentiation. Periostin expression and knock-down was evaluated on Differentiation of cushion mesenchymal cells into valve fibroblasts and collagen I protein expression. Periostin, regulated by TGFbeta-3, promotes mesenchymal-to-fibroblast differentiation and collagen I production in chick atrioventricular valve maturation while blocking myocyte differentiation.
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