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June 16, 2010Journal of Clinical InvestigationOpen Access

Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents

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Population

Human atherosclerotic and rheumatic valvular heart disease tissue samples, wild-type mice on high-fat diet…

Comparison

Periostin knockout and periostin exposure vs Wild-type mice, normal human valves, and…

Design

Preclinical

Authors

DHDaihiko HakunoKawasaki Municipal Hospital NKNaritaka KimuraKeio University MYMasatoyo YoshiokaKyushu University

Discussion

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Implication

Periostin may represent a target in experimental valve degeneration; hypothesis-generating and should not yet change clinical practice.

Structured PICO

P

Population

Human atherosclerotic and rheumatic valvular heart disease tissue samples, wild-type mice on high-fat diet, periostin-knockout mice, and cultured valvular interstitial cells, endothelial cells, and macrophages

I

Intervention

Periostin knockout (in vivo) and periostin exposure (in vitro/ex vivo)

C

Comparator

Wild-type mice, normal human valves, and untreated cells

O

Outcome

Cardiac valve degeneration (aortic valve thickening, annular fibrosis, angiogenesis, and MMP production)surrogate

Periostin plays an essential role in the progression of cardiac valve degeneration by inducing angiogenesis and MMP production, suggesting a potential therapeutic target for valvular heart disease.

Cite This Study

Hakuno et al. (2010) studied this question.

synapsesocial.com/papers/6a7dff871a9d4ca5f9ac90e4 https://doi.org/10.1172/jci40973

Topics

Valvular heart disease

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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

1Calcified Rheumatic Valve Neoangiogenesis Is Associated With Vascular Endothelial Growth Factor Expression and Osteoblast-Like Bone Formation2005 · 162 citations
2Stability analysis of latent and active 72-kDa type IV collagenase: The role of tissue inhibitor of metalloproteinases-2 (TIMP-2)1993 · 88 citations
3Identification and Characterization of a Novel Protein, Periostin, with Restricted Expression to Periosteum and Periodontal Ligament and Increased Expression by Transforming Growth Factor β1999 · 1,007 citations
4Angiogenesis in osteoarthritis2008 · 166 citations