Key result
Overexpression of the periostin gene in rat hearts led to cardiac dysfunction and LV dilation, while its inhibition significantly increased survival and improved LV function.
Why the study?
Does periostin overexpression cause ventricular dilation, and does its inhibition improve survival and LV function in rat models of heart failure?
Does periostin overexpression cause ventricular dilation, and does its inhibition improve survival and LV function in rat models of heart failure?
Periostin is identified as a novel factor contributing to ventricular dilation, and its inhibition represents a potential new therapeutic target for heart failure.
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Periostin inhibition improves rat HF outcomes; leaves open translation to human therapy.
Katsuragi et al. (2004) studied Heart failure and ventricular dilation. Periostin gene transfection and antisense inhibition vs. Control (implied) was evaluated on Left ventricular dilation, cardiac dysfunction, and survival rate. Overexpression of the periostin gene in rat hearts led to cardiac dysfunction and LV dilation, while its inhibition significantly increased survival and improved LV function.
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