Key result
Chronic renal insufficiency in rats resulted in a 6.5-fold increase in left ventricular periostin mRNA levels, which correlated with biomarkers of impaired kidney function and fibrogenesis.
Why the study?
Does chronic renal insufficiency induce left ventricular periostin gene expression and fibrogenesis in experimental rat models?
Population
Rats (5/6-nephrectomized, spontaneously hypertensive, and those subjected to angiotensin II or…
Design
Preclinical
Follow-up
15 weeks of disease progression followed by 12 weeks of…
Authors
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Periostin upregulation may mediate experimental cardiorenal fibrosis; leaves open human relevance and therapeutic targeting.
Does chronic renal insufficiency induce left ventricular periostin gene expression and fibrogenesis in experimental rat models?
Effect estimate: 6.5-fold increase
Periostin is upregulated in chronic renal insufficiency-induced cardiac remodeling and localizes to fibrotic and inflammatory lesions, likely driven by elevated blood pressure.
Pohjolainen et al. (2011) studied Chronic renal insufficiency and left ventricular hypertrophy. Chronic renal insufficiency (5/6-nephrectomy) was evaluated on Left ventricular periostin gene expression (mRNA levels) (6.5-fold increase). Chronic renal insufficiency in rats resulted in a 6.5-fold increase in left ventricular periostin mRNA levels, which correlated with biomarkers of impaired kidney function and fibrogenesis.
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