What question did this study set out to answer?

To evaluate the optimal extent of therapeutic blood pressure reduction and assess the clinical validity and mechanisms of the J-curve phenomenon.

How Far Should Blood Pressure Be Lowered?: What Is the Role of the J-Curve?

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Review examines blood pressure lowering thresholds in hypertensive patients, highlighting the clinical implications of the J-curve phenomenon.

To evaluate the optimal extent of therapeutic blood pressure reduction and assess the clinical validity and mechanisms of the J-curve phenomenon.
Clinical review analyzing epidemiological data and therapeutic trials on target blood pressure thresholds in hypertensive individuals.
Investigation of perfusion dynamics and adverse outcome curves associated with progressive reductions in diastolic blood pressure.
Highlights evidence suggesting that while lowering elevated blood pressure reduces cardiovascular risk, excessive reduction may paradoxically increase coronary events.
Identifies critical diastolic thresholds beyond which myocardial perfusion may become compromised in individuals with underlying coronary artery disease.

L. Hansson (1990) studied this question.

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Review examines blood pressure lowering thresholds in hypertensive patients, highlighting the clinical implications of the J-curve phenomenon.