January 1, 1989Journal of Hypertension
How much should blood pressure be lowered? The problem of the J-shaped curve
Why the study?
How much should blood pressure be lowered considering the J-shaped curve?
Design
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Authors
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Implication
This paper discusses the optimal target for blood pressure lowering and the potential risks associated with the J-shaped curve.
Key Points
- To evaluate the optimal extent of blood pressure reduction during antihypertensive therapy and assess the clinical validity of the J-shaped curve relationship.
- Clinical review of trial data and observational evidence assessing outcomes at varying achieved blood pressure levels.
- Analysis of coronary perfusion and organ hypoperfusion risks associated with intense diastolic blood pressure lowering.
- Identifies evidence suggesting that while lowering elevated blood pressure reduces stroke and cardiovascular events, excessive reduction may increase myocardial infarction risk.
- Indicates that the J-shaped curve is particularly pronounced for coronary events in patients with preexisting ischemic heart disease.
Cite This Study
Zanchetti et al. (1989) studied this question.