Key result
Lowering diastolic blood pressure below 85 mm Hg in hypertensive patients was associated with a higher myocardial infarction rate (3.7%) compared to a moderate reduction of 7 to 17 mm Hg (0.9%).
Why the study?
Does lowering diastolic blood pressure below 85 mm Hg increase the incidence of myocardial infarction in patients with essential hypertension?
Population
Patients with essential hypertension
Comparison
Reduction of diastolic blood pressure below 85… vs Moderate reduction of diastolic blood pressure
Design
Editorial
Authors
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Overenthusiastic reduction of diastolic blood pressure below 85 mm Hg in essential hypertension may be detrimental and increase the risk of myocardial infarction due to a J-curve effect.
Does lowering diastolic blood pressure below 85 mm Hg increase the incidence of myocardial infarction in patients with essential hypertension?
Absolute Event Rate: 3.7% vs 0.9%
Overenthusiastic reduction of diastolic blood pressure below 85 mm Hg in essential hypertension may be detrimental and increase the risk of myocardial infarction due to a J-curve effect.
Suman Vardan (1991) conducted a letter in essential hypertension. Diastolic blood pressure reduction below 85 mm Hg vs. Diastolic blood pressure reduction between 7 and 17 mm Hg was evaluated on myocardial infarction. Lowering diastolic blood pressure below 85 mm Hg in hypertensive patients was associated with a higher myocardial infarction rate (3.7%) compared to a moderate reduction of 7 to 17 mm Hg (0.9%).
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