Synthesis of (+)-Boronolide from d-Glucose

Abstract (+)-Boronolide (= (1′R,2′R,3′S,6R)-5,6-dihydro-6-[1′,2′,3′-tris(acetoxy)heptyl]-2H-pyran-2-one) (1), a constituent isolated from Tetradenia fruticosa and T. barberae (Lamiaceae), was synthesized in 7 steps and in 5.2% overall yield from 2,3,4,5,6-penta-O-benzyl-d-glucose, whose four asymmetric centers were incorporated in 1.