From Migraine Headache: A Case ReportBackground: Ergotamine is a very common antimigraine and is widely used in the management of headaches such as cluster and acute migraines.However, Ergotamine poisoning is an infrequent condition, and there are very few cases reported.Tachycardia and arterial spasms occasionally occur because of accidental overdosing or interactions.There are no specific antidotes, and none of the current treatments have proven efficacy.Case Report: Here, we describe a young female who intentionally consumed approximately 20 mg of ergotamine and experienced vomiting, vasospasm, and tachycardia.Fortunately, her symptoms improved with the administration of conservation therapy, enoxaparin, nifedipine, and methylprednisolone. Conclusion:Clinicians should be aware of the potential risk of vasoconstriction associated with ergotamine/caffeine toxicity and closely monitor patients for these side effects.
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Farzaneh et al. (2025) studied this question.