What question did this study set out to answer?

To determine whether human Timeless coordinates circadian clock function with cell cycle DNA damage checkpoint responses.

March 29, 2005Molecular and Cellular BiologyOpen Access

Coupling of Human Circadian and Cell Cycles by the Timeless Protein

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Authors

KÜKeziban Ünsal-KaçmazBristol-Myers Squibb (United States)TMThomas E. MullenBroad Institute WKWilliam K. KaufmannUniversity of North Carolina at Chapel Hill

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Implication

Cellular study demonstrates that human Timeless bridges circadian control and DNA damage checkpoints, indicating direct coupling between clock and cell cycle machinery.

Key Points

To determine whether human Timeless coordinates circadian clock function with cell cycle DNA damage checkpoint responses.
Assessed physical interactions between human Timeless, the circadian clock protein cryptochrome 2, and cell cycle checkpoint regulators (Chk1 and ATR-ATRIP).
Examined the effects of down-regulating Timeless expression on replication and intra-S phase DNA damage checkpoints in human cells.
Human Timeless physically associates with cryptochrome 2 as well as the ATR-ATRIP complex and Chk1.
Down-regulation of Timeless in human cells severely compromises replication and intra-S DNA damage checkpoints.

Cite This Study

Ünsal-Kaçmaz et al. (2005) studied this question.

synapsesocial.com/papers/6a71af8975498292b70b150d https://doi.org/10.1128/mcb.25.8.3109-3116.2005

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Implication

Cellular study demonstrates that human Timeless bridges circadian control and DNA damage checkpoints, indicating direct coupling between clock and cell cycle machinery.

Coupling of Human Circadian and Cell Cycles by the Timeless Protein

Discussion

Member takes

Implication

Key Points

Cite This Study

Coupling of Human Circadian and Cell Cycles by the Timeless Protein

Discussion

Member takes

Implication

Key Points

Cite This Study

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