Key result
Diethyl Blechnic protected cardiomyocytes against doxorubicin-induced cytotoxicity and apoptosis by inhibiting reactive oxygen species generation and activating the JNK1/2 pathway.
Why the study?
Does Diethyl Blechnic protect cardiomyocytes against doxorubicin-induced apoptosis?
Population
H9c2 cells and primary cultured cardiomyocytes
Comparison
Diethyl Blechnic (DB) vs Doxorubicin alone (implied)
Design
Preclinical
Authors
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Diethyl blechnic may mitigate doxorubicin cardiotoxicity in vitro; hypothesis-generating and requires in vivo and clinical validation.
Does Diethyl Blechnic protect cardiomyocytes against doxorubicin-induced apoptosis?
Diethyl Blechnic protects cardiomyocytes against doxorubicin-induced cytotoxicity by inhibiting ROS and activating the JNK1/2 pathway, highlighting its potential as a cardioprotective agent.
Yu et al. (2018) studied Doxorubicin-induced cardiotoxicity. Diethyl Blechnic vs. Doxorubicin alone was evaluated on Apoptosis and cytotoxicity. Diethyl Blechnic protected cardiomyocytes against doxorubicin-induced cytotoxicity and apoptosis by inhibiting reactive oxygen species generation and activating the JNK1/2 pathway.
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