September 13, 2023International Journal of Molecular SciencesOpen Access

α-Bisabolol, a Dietary Sesquiterpene, Attenuates Doxorubicin-Induced Acute Cardiotoxicity in Rats by Inhibiting Cellular Signaling Pathways, Nrf2/Keap-1/HO-1, Akt/mTOR/GSK-3β, NF-κB/p38/MAPK, and NLRP3 Inflammasomes Regulating Oxidative Stress and Inflammatory Cascades

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Why the study?

Cancer chemotherapy with doxorubicin causes multiorgan toxicities, particularly cardiotoxicity, which represents a major limitation of its clinical use.

Does α-Bisabolol attenuate doxorubicin-induced acute cardiotoxicity in rats?

Population

Rats with DOX-induced acute cardiotoxicity

Comparison

BSB (25 mg/kg orally twice daily) vs DOX alone

Design

Animal experimental study

Follow-up

Five days

Authors

MMMohamed Fizur Nagoor MeeranThiruvalluvar University SASeenipandi ArunachalamUnited Arab Emirates University SASheikh AzimullahUppsala University

Discussion

Member takes

Implication

α-Bisabolol merits dose-optimization studies in larger models; leaves open clinical translation for doxorubicin cardiotoxicity prevention.

Structured PICO

Does α-Bisabolol attenuate doxorubicin-induced acute cardiotoxicity in rats?

Population

Rats with doxorubicin-induced acute cardiotoxicity (induced by 12.5 mg/kg single intraperitoneal dose)

Intervention

α-Bisabolol (BSB) 25 mg/kg orally twice daily for 5 days

Comparator

Doxorubicin alone (implied)

Outcome

Cardiac dysfunction, oxidative stress, inflammatory markers, and histopathological alterationssurrogate

α-Bisabolol demonstrates cardioprotective effects against doxorubicin-induced acute cardiotoxicity in rats by modulating multiple oxidative and inflammatory signaling pathways.

Limitations

Lack of tumor-bearing animal models
Lack of regulatory toxicology studies

Cite This Study

Meeran et al. (2023) studied this question.

synapsesocial.com/papers/6a71672ca528af2d65c40f4a https://doi.org/10.3390/ijms241814013

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Implication

α-Bisabolol merits dose-optimization studies in larger models; leaves open clinical translation for doxorubicin cardiotoxicity prevention.

α-Bisabolol, a Dietary Sesquiterpene, Attenuates Doxorubicin-Induced Acute Cardiotoxicity in Rats by Inhibiting Cellular Signaling Pathways, Nrf2/Keap-1/HO-1, Akt/mTOR/GSK-3β, NF-κB/p38/MAPK, and NLRP3 Inflammasomes Regulating Oxidative Stress and Inflammatory Cascades

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

α-Bisabolol, a Dietary Sesquiterpene, Attenuates Doxorubicin-Induced Acute Cardiotoxicity in Rats by Inhibiting Cellular Signaling Pathways, Nrf2/Keap-1/HO-1, Akt/mTOR/GSK-3β, NF-κB/p38/MAPK, and NLRP3 Inflammasomes Regulating Oxidative Stress and Inflammatory Cascades

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider