Key result
In rat and mouse models of hypertension, the functional impact of Kv7 channels was dramatically downregulated, with Kv7.4 protein levels reduced by approximately 50% compared to normotensive vessels.
Population
Normotensive and hypertensive animal models
Comparison
Kv7 channel activators vs Normotensive control animals
Design
Preclinical
Authors
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Kv7.4 downregulation in hypertensive rodent vessels is hypothesis-generating; leaves open any therapeutic role in human hypertension.
Kv7.4 channel activity and expression are significantly downregulated in primary and secondary hypertension models, suggesting a role in vascular dysfunction.
Jepps et al. (2011) studied Hypertension. Kv7 activators (BMS-204352, S-1, and retigabine) vs. Normotensive controls was evaluated on Vascular relaxation, coronary flow, K+ currents, and Kv7.4 protein levels. In rat and mouse models of hypertension, the functional impact of Kv7 channels was dramatically downregulated, with Kv7.4 protein levels reduced by approximately 50% compared to normotensive vessels.
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