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March 1, 1989The Journal of PhysiologyOpen Access

Some electrical properties of the endothelium‐dependent hyperpolarization recorded from rat arterial smooth muscle cells.

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Population

Rat arterial smooth muscle cells from intralobular small pulmonary artery, main pulmonary artery, and…

Comparison

Acetylcholine (ACh) and histamine vs Control conditions

Design

Preclinical

Authors

GCG ChenHSHiroetsu Suzuki

Discussion

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Overview

Endothelium-dependent hyperpolarization may mediate relaxation in rat arteries; leaves open its identity and relevance to human vessels.

Key Points

  • The aim is to explore how acetylcholine and histamine influence hyperpolarization in arterial smooth muscle cells of rats.
  • Recorded electrical responses from smooth muscle cells of the intralobular small pulmonary artery, main pulmonary artery, and thoracic aorta.
  • Investigated the effects of acetylcholine and histamine on membrane hyperpolarization.
  • Analyzed the role of potassium conductance and intact endothelial cells in this process.
  • Acetylcholine and histamine induced transient hyperpolarization in MPA and SPA, decaying over 2-3 minutes.
  • Hyperpolarization was blocked by atropine and mepyramine, confirming receptor involvement.
  • In aorta, acetylcholine prompted sustained relaxation, while histamine caused a transient response, highlighting differences in relaxation mechanisms.

Structured PICO

P
Population
Rat arterial smooth muscle cells from intralobular small pulmonary artery (SPA), main pulmonary artery (MPA), and thoracic aorta
I
Intervention
Acetylcholine (ACh) and histamine
C
Comparator
Control conditions (endothelium removal, receptor antagonists atropine/mepyramine, altered potassium solutions)
O
Outcome
Membrane hyperpolarization and tissue relaxationsurrogate

In rat arteries, acetylcholine and histamine release an endothelium-derived hyperpolarizing substance that increases potassium conductance and contributes to vasorelaxation.

Cite This Study

Chen et al. (1989) studied this question.

synapsesocial.com/papers/6a71b30226a7f98052ddedbbhttps://doi.org/10.1113/jphysiol.1989.sp017522
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Also Consider

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  1. 1Membrane properties of smooth muscle cells in pulmonary arteries of the rat1982 · 31 citations
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  4. 4Factors modifying contraction-relaxation cycle in vascular smooth muscles1982 · 230 citations
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