Population
Isolated coronary arteries from mongrel dogs, human cadavers, pigs, and rhesus monkeys, as well as canine…
Comparison
Potassium channel blockers, primarily… vs Untreated adjacent arterial rings or…
Design
Preclinical
Follow-up
up to 11 hours (in vitro observation)
Authors
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Hypothesis-generating for potassium channel dysfunction in variant angina; human studies needed before any clinical consideration.
Potassium channel blockers induce phasic contractions in isolated coronary arteries, suggesting that potassium channel dysfunction and subsequent calcium influx may underlie coronary vasospasm in variant angina.
Uchida et al. (1986) studied this question.
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