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April 1, 1983Circulation ResearchOpen Access

Coronary artery spasm in intact dogs induced by potassium and serotonin.

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Why the study?

Does topical application of potassium or serotonin induce reversible segmental coronary artery spasm in open-chest dogs?

Population

Open-chest dogs

Comparison

Topical application of vasoconstricting agents… vs Other constrictors including norepinephrine and…

Design

Preclinical

Authors

JPJulio E. PérezUniversidad de OrienteJSJeffrey E. SaffitzElectrophysiologyFGFernanda A. GutierrezUniversidad de Guadalajara

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Implication

Provides a reversible canine model of coronary spasm; leaves open translation to human vasospastic disease.

Structured PICO

Does topical application of potassium or serotonin induce reversible segmental coronary artery spasm in open-chest dogs?

P
Population
Open-chest dogs
I
Intervention
Topical application of vasoconstricting agents (potassium and serotonin) adsorbed to viscous ion exchange gels to the surface of epicardial coronary arteries
C
Comparator
Other constrictors including norepinephrine and angiotensin
O
Outcome
Segmental arterial constrictor responses and coronary flow reductionsurrogate

Topical application of potassium and serotonin successfully induces a reversible, nonthrombotic, vasodilator-sensitive model of coronary artery spasm in intact dogs.

Cite This Study

Pérez et al. (1983) studied this question.

synapsesocial.com/papers/6a902db06bfd95d7bd4dccd8https://doi.org/10.1161/01.res.52.4.423
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