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February 1, 1987Cardiovascular Research

Tetraethylammonium induced coronary spasm in isolated perfused rabbit heart: a hypothesis for the mechanism of coronary spasm

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Population

114 isolated perfused rabbit hearts

Design

Preclinical

Authors

MIMasahiro IwakiKindai UniversitySMShigeki MizobuchiTokushima UniversityYNYosuke NakayaMetropolitan University

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Implication

Hypothesis-generating for potassium permeability defects in variant angina; requires human confirmation before any clinical relevance.

Structured PICO

P
Population
114 isolated perfused rabbit hearts
I
Intervention
Tetraethylammonium (30 mmol.litre-1)
O
Outcome
Induction of severe constriction of the left epicardial coronary artery (coronary spasm)surrogate

Tetraethylammonium induces coronary spasm in isolated rabbit hearts, supporting the hypothesis that decreased potassium permeability in coronary arterial smooth muscle cells may be a primary defect in variant angina.

Cite This Study

Iwaki et al. (1987) studied this question.

synapsesocial.com/papers/6a71b3185d37378ac1dec6aehttps://doi.org/10.1093/cvr/21.2.130
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Coronary artery spasm in intact dogs induced by potassium and serotonin.1983 · 28 citations
  2. 2alpha-Adrenergic receptors and coronary spasm: an elusive link.1984 · 108 citations
  3. 3Attenuation of endothelium-related relaxation and enhanced responsiveness of vascular smooth muscle to histamine in spastic coronary arterial segments from miniature pigs.1987 · 73 citations
  4. 4Serotonin-induced coronary spasm in a swine model. A minor role of defective endothelium-derived relaxing factor.1993 · 39 citations
  5. 5Reduction of coronary blood flow during coronary artery spasm occurring spontaneously and after provocation by ergonovine maleate.1978 · 49 citations