Key result
Adult survivors with single-ventricle physiology generally reported good patient-reported outcomes, with those in Ability Index class I having scores similar to healthy controls.
Why the study?
Do adult survivors with single-ventricle physiology have different patient-reported outcomes compared to healthy controls?
Case-Control (n=234)
Yes
Do adult survivors with single-ventricle physiology have different patient-reported outcomes compared to healthy controls?
Adult survivors with single-ventricle physiology generally have good patient-reported outcomes, with those in the best functional class scoring similarly to healthy controls.
Supports optimistic counseling for adult single-ventricle survivors; extends limited adult data but leaves open durability with aging.
OBJECTIVES: Data on patient-reported outcomes (PROs) in patients with single-ventricle physiology (SVP) are scarce. We sought (1) to describe the perceived health status, quality of life, symptoms of anxiety and depression, and sense of coherence in adult survivors with SVP, (2) to compare PROs across functional classes, and (3) to compare PROs between patients and controls. METHODS: A case-control study in two adult congenital heart programmes with 62 adult survivors with SVP were matched to 172 healthy controls. A wide range of PROs were measured using validated questionnaires. The treating physician classified patients according to the Ability Index. RESULTS: Patients with SVP have a good functional status. Patients in Ability Index class I consistently reported the best scores, similar to those of healthy controls. Negative associations were found between functional class and outcomes of perceived health and quality of life. For patients in Ability Index class II and III, PROs were poorer. CONCLUSIONS: PROs in patients with SVP are generally good.
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Overgaard et al. (2011) conducted a case-control in Single-ventricle physiology (n=234). Single-ventricle physiology vs. Healthy controls was evaluated on Patient-reported outcomes (perceived health status, quality of life, symptoms of anxiety and depression, and sense of coherence). Adult survivors with single-ventricle physiology generally reported good patient-reported outcomes, with those in Ability Index class I having scores similar to healthy controls.
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