September 1, 1982AJP Renal Physiology

Renin release selectively stimulated by prostaglandin I2 in isolated rat glomeruli

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Population

Isolated renal glomeruli from rat kidneys

Comparison

Superfusion with arachidonic acid (1.6 x 10 M)… vs Superfusion with other prostaglandins, lower…

Design

Preclinical

Authors

WBW. H. BeierwaltesWest Virginia University SSS. SchryverAlrijne Ziekenhuis ESElizabeth A. SandersUniversity of Washington

Discussion

Member takes

Implication

PGI2 selectively mediates renin release in isolated rat glomeruli; hypothesis-generating for human renal physiology and requires in vivo confirmation.

Structured PICO

Population

Isolated renal glomeruli from rat kidneys

Intervention

Superfusion with arachidonic acid (1.6 x 10(-4) M) or PGI2 (1.7 x 10(-4) M or stabilized at pH 9.4)

Comparator

Superfusion with other prostaglandins (PGE1, PGE2, PGF2 alpha, TXB2, PGD2, stable analog of PGH2), lower concentration of arachidonic acid (1.6 x 10(-5) M), or PGI2 synthesis inhibitor (azo analog 1)

Outcome

Renin releasesurrogate

In isolated rat glomeruli, the direct interaction between renal prostaglandins and renin release is selectively mediated by PGI2.

Cite This Study

Beierwaltes et al. (1982) studied this question.

synapsesocial.com/papers/6a71b4dfa528af2d65c42da0 https://doi.org/10.1152/ajprenal.1982.243.3.f276

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Implication

PGI2 selectively mediates renin release in isolated rat glomeruli; hypothesis-generating for human renal physiology and requires in vivo confirmation.

Renin release selectively stimulated by prostaglandin I2 in isolated rat glomeruli

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Renin release selectively stimulated by prostaglandin I2 in isolated rat glomeruli

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider