Why the study?
Does intravenous prostacyclin stimulate renin release in healthy human subjects?
Population
12 healthy human subjects (6 men for PGI2/6-keto-PGF1alpha infusion, 6 women for furosemide infusion)
Comparison
Intravenous prostacyclin or 6-keto-PGF1alpha… vs Baseline levels; 6-keto-PGF1alpha infusion as a…
Design
Other
Authors
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PGI2 may raise renin activity independently of beta-blockade; leaves open relevance to prostacyclin therapy or disease states.
Does intravenous prostacyclin stimulate renin release in healthy human subjects?
Prostacyclin directly stimulates renin release in humans through a mechanism independent of adrenergic stimuli or hemodynamic changes.
Pugliese et al. (1982) studied this question.
Synapse has enriched one closely related paper. Consider it for comparative context: