Why the study?
Do Angiotensin II receptor antagonists prevent intimal hyperplasia in a porcine coronary artery model of vascular injury?
Population
Porcine coronary artery model of vascular injury and rat carotid artery model of balloon dilatation.
Comparison
Infusion of Angiotensin II receptor antagonists… vs Vehicle-treated controls.
Design
Preclinical
Follow-up
28 days
Authors
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Does not justify clinical trials of these agents for restenosis; leaves open Ang II's role in human neointimal hyperplasia.
Do Angiotensin II receptor antagonists prevent intimal hyperplasia in a porcine coronary artery model of vascular injury?
Angiotensin II receptor antagonists do not inhibit intimal hyperplasia after experimental coronary stenting in a porcine model, suggesting Ang II is not a major mediator of restenosis in this setting.
Huckle et al. (1996) studied this question.
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