Key result
Among 1,137 patients, inferior vena cava filters did not significantly reduce the risk of pulmonary embolism compared to non-IVCF, but significantly increased the risk of deep-vein thrombosis.
Why the study?
To assess the treatment effectiveness of inferior vena cava filters versus non-inferior vena cava filters in patients under various conditions.
Do inferior vena cava filters (IVCF) prevent pulmonary embolism in patients undergoing various conditions?
Meta-Analysis (n=1,137)
Do inferior vena cava filters (IVCF) prevent pulmonary embolism in patients undergoing various conditions?
The use of inferior vena cava filters does not prevent pulmonary embolism and is associated with a significantly increased risk of deep-vein thrombosis.
OBJECTIVES: To assess the treatment effectiveness of inferior vena cava filters (IVCF) versus non-IVCF for patients undergoing varies conditions. METHODS: We systematically searched the databases to identify eligible RCTs from their inception up to 9/20/2020. The primary endpoint was pulmonary embolism (PE), while the secondary endpoints included deep-vein thrombosis (DVT), major bleeding, and all-cause mortality. The RRs with 95% CIs were applied as effect estimates for the treatment effectiveness of IVCF versus non-IVCF and calculated by using the random-effects model. RESULTS: 1,137 patients of 5 RCTs were enrolled. There were no significant differences between IVCF and non-IVCF for the risk of PE, major bleeding, and all-cause mortality, while the risk of DVT was significantly increased for patients treated with IVCF. CONCLUSIONS: The use of IVCF did not yield any benefits on PE, major bleeding, and all-cause mortality risk for patients undergoing various conditions, while the risk of DVT was significantly increased for patients treated with IVCF.
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Miao et al. (2023) conducted a meta-analysis in various conditions (n=1,137). inferior vena cava filters (IVCF) vs. non-IVCF was evaluated on pulmonary embolism (PE). Among 1,137 patients, inferior vena cava filters did not significantly reduce the risk of pulmonary embolism compared to non-IVCF, but significantly increased the risk of deep-vein thrombosis.
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