October 1, 1968Proceedings of the National Academy of SciencesOpen Access

The relationship between red cell 2,3-diphosphoglycerate and levels of hemoglobin in the human.

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Population

300 healthy adults, including 200 males from a state prison and 100 females from a hospital outpatient…

Design

Cross-sectional

Authors

JEJohn W. EatonUniversity of Louisville Hospital GBGeorge J. BrewerBaptist Memorial Hospital

Discussion

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Implication

Association does not establish causality; hypothesis-generating for DPG-hemoglobin regulation and requires prospective studies.

Structured PICO

Population

300 healthy adults, including 200 males (100 Caucasian, 100 Negro) from a state prison and 100 females (59 Caucasian, 41 Negro) from a hospital outpatient laboratory.

Outcome

Correlation between red cell 2,3-diphosphoglycerate (DPG) and whole blood hemoglobin levelssurrogate

There is a significant inverse relationship between red cell 2,3-DPG and whole blood hemoglobin levels, suggesting DPG variation may be causally related to physiological variation in hemoglobin levels.

Limitations

The negative correlation reported does not necessarily prove a causal relationship between DPG and hemoglobin.

Cite This Study

Eaton et al. (1968) studied this question.

synapsesocial.com/papers/6a71b69031a3df824329c52f https://doi.org/10.1073/pnas.61.2.756

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The relationship between red cell 2,3-diphosphoglycerate and levels of hemoglobin in the human.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

The relationship between red cell 2,3-diphosphoglycerate and levels of hemoglobin in the human.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider