Key result
The Cardio-Ankle Vascular Index (CAVI) was significantly and independently correlated with carotid intima-media thickness (β 0.81, p<0.001) in Japanese adults from the general population.
Why the study?
Does the Cardio-Ankle Vascular Index (CAVI) correlate with existing markers of atherosclerosis in the general population?
Cross-Sectional (n=1,014)
No
Does the Cardio-Ankle Vascular Index (CAVI) correlate with existing markers of atherosclerosis in the general population?
Effect estimate: β 0.81 (95% CI 0.37, 1.26)
p-value: p=<0.001
CAVI correlates significantly with established markers of atherosclerosis, suggesting its potential utility as a non-invasive screening tool.
CAVI may aid noninvasive atherosclerosis assessment; leaves open its prognostic role pending longitudinal validation.
BACKGROUND: A novel index, the cardio-ankle vascular index (CAVI), which reflects the stiffness of the aorta, femoral artery, and tibial artery, was recently developed by measuring brachial - ankle pulse wave velocity and blood pressure. METHODS AND RESULTS: In the present study 1,014 Japanese adults from the general population were screened to clarify the correlation between CAVI and other existing markers related to atherosclerosis, including carotid intima - media thickness (CIMT) and homocysteine (HCY). CAVI was strongly associated with age in both men and women. After adjustment for age and sex, CAVI was correlated with systolic and diastolic blood pressures. In addition, CAVI was significantly correlated with total cholesterol hemoglobin A(1c) and total HCY, as well as CIMT. CONCLUSION: CAVI is an appropriate screening tool for atherosclerosis, but further studies are needed to establish a convenient and effective screening system using it.
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Kadota et al. (2008) conducted a cross-sectional in Atherosclerosis screening (n=1,014). Cardio-Ankle Vascular Index (CAVI) was evaluated on Correlation between CAVI and carotid intima-media thickness (CIMT) adjusted for confounding factors (β 0.81, 95% CI 0.37, 1.26, p=<0.001). The Cardio-Ankle Vascular Index (CAVI) was significantly and independently correlated with carotid intima-media thickness (β 0.81, p<0.001) in Japanese adults from the general population.
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