Population
Fragmented sarcoplasmic reticulum (FSR) isolated from cat, guinea pig and frog cardiac muscles
Comparison
Ouabain (2 × 10-6 M) treatment for 1 min vs Control conditions
Design
Preclinical
Authors
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Supports ouabain inotropy via SR Ca release in animals; hypothesis-generating and leaves open human relevance.
Ouabain potentiates calcium release from cardiac sarcoplasmic reticulum, suggesting a mechanism for its positive inotropic action.
Fujino et al. (1979) studied this question.
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