Key result
Metabolic syndrome in young patients with abdominal obesity was associated with significantly higher common carotid artery intima-media thickness compared to healthy volunteers (median 0.56 vs 0.49; p=0.025).
Why the study?
To evaluate CCA IMT, the presence of atherosclerotic plaques, and their relationship with fat depots in young people with abdominal obesity with or without metabolic syndrome.
Does abdominal obesity with or without metabolic syndrome affect common carotid artery intima-media thickness and the presence of atherosclerotic plaques in young patients?
Cross-Sectional (n=145)
Does abdominal obesity with or without metabolic syndrome affect common carotid artery intima-media thickness and the presence of atherosclerotic plaques in young patients?
Absolute Event Rate: 0.56% vs 0.49%
p-value: p=0.025
In young patients, metabolic syndrome is associated with increased carotid intima-media thickness, and even metabolically healthy abdominal obesity is associated with a higher presence of atherosclerotic plaques compared to healthy controls.
May support early vascular monitoring in young patients with metabolic syndrome; leaves open causal progression and intervention effects.
Aim. To evaluate the common carotid artery (CCA) intima-media complex thickness (IMT) and the presence of atherosclerotic plaques (ASP) in young people with abdominal obesity who don’t have metabolic syndrome and those who have it, as well as a link between fat depots (perivascular, visceral, subcutaneous, epicardial) and CCA IMT. Materials and methods. The study included 145 people aged 18-45 years. They were divided into 3 groups: group 1 (n=18) - healthy volunteers (control group), group 2 (n=48) - patients with abdominal obesity and no more than one additional risk factor (metabolically healthy) and group 3 (n=79) - patients with metabolic syndrome. In persons included in the study the following parameters were measured: the height, weight, body mass index, waist circumference, fasting blood glucose, glucose tolerance, uric acid, lipid profile, insulin and the insulin resistance index (HOMA-IR). They also were given a 24-hour blood pressure monitoring, and an evaluation of CCA IMT, a presence of ASP in the carotid arteries and a maximum degree of internal carotid stenosis was performed using the duplex scan of brachiocephalic arteries. Computed tomography (Aquilion One Vision Edition, Toshiba, Japan) with determining subcutaneous, visceral, perivascular, epicardial fat was performed, and the ratio of subcutaneous to visceral fat was calculated. Results. Significant differences in mean CCA IMT were revealed only between persons of group 1 and group 3 (p=0.025), while the median of IMT were within normal ranges (group 1: 0.49 [0.46; 0.56]; group 2: 0.53 [0.49; 0.59]; group 3: 0.56 [0.52; 0.62]). Significant differences in a distribution of individuals with increased IMT between groups were also not revealed. However, the proportion of individuals with ASP was significantly higher in group 2 compared with group 1 (p
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Zheleznova et al. (2019) conducted a cross-sectional in Abdominal obesity (n=145). Metabolic syndrome vs. Healthy volunteers was evaluated on Common carotid artery intima-media thickness (CCA IMT) (p=0.025). Metabolic syndrome in young patients with abdominal obesity was associated with significantly higher common carotid artery intima-media thickness compared to healthy volunteers (median 0.56 vs 0.49; p=0.025).
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