Association of Metabolic Syndrome with the Cardioankle Vascular Index in Asymptomatic Korean Population

Q: What are the key findings of this study?

Metabolic syndrome was associated with higher cardioankle vascular index values compared to no metabolic syndrome.

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Metabolic syndrome in an asymptomatic Korean population (n=1144). Intervention: Metabolic syndrome (NCEP-ATPIII and WHO Asia Pacific criteria) vs. Subjects without metabolic syndrome. Primary outcome: Cardioankle vascular index (CAVI) (β = 0.143, p=0.04).

Q: What does this research mean for the field?

Metabolic syndrome is significantly associated with higher cardioankle vascular index values, with arterial stiffness increasing linearly with the number of metabolic syndrome components. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

Suhyun Nam; Sung Goo Kang; Yun-Ah Lee; Sang-Wook Song; Jun-Seung Rho

doi:10.1155/2015/328585

January 1, 2015Journal of Diabetes ResearchOpen Access

Association of Metabolic Syndrome with the Cardioankle Vascular Index in Asymptomatic Korean Population

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Key result

Metabolic syndrome is linked to higher cardioankle vascular index values versus no metabolic syndrome.

β = 0.143
P=0.04
n=1,144

Why the study?

Is metabolic syndrome associated with increased arterial stiffness as measured by the cardioankle vascular index (CAVI) in an asymptomatic Korean population?

Study Design

Type

Cross-Sectional (n=1,144)

Multicenter

No

Structured PICO

Is metabolic syndrome associated with increased arterial stiffness as measured by the cardioankle vascular index (CAVI) in an asymptomatic Korean population?

P

Population

1,144 asymptomatic Korean adults (69% men, 32.7% with metabolic syndrome) undergoing a physical examination at a single center, excluding those with prior cancer, heart disease, or peripheral vascular disease.

E

Exposure

Presence of metabolic syndrome defined by NCEP-ATPIII (2005) and WHO Asia Pacific criteria (presence of ≥3 of: abdominal obesity [waist circumference ≥90 cm in men, ≥85 cm in women], triglycerides ≥150 mg/dL or treatment, HDL-C <40 mg/dL in men or <50 mg/dL in women or treatment, blood pressure ≥130/85 mmHg or treatment, fasting glucose ≥100 mg/dL or treatment).

C

Comparator

Absence of metabolic syndrome (<3 metabolic syndrome risk factors).

O

Outcome

Cardioankle vascular index (CAVI) measured noninvasively using a Vasera VS-1000 system.surrogate

Main Result

Effect estimate: β = 0.143

Absolute Event Rate: 7.55% vs 7.41%

p-value: p=0.04

Metabolic syndrome and an increasing number of its individual components are significantly associated with elevated arterial stiffness as measured by CAVI in asymptomatic Korean adults, with age, sex, diastolic blood pressure, and uric acid acting as independent predictors.

Limitations

Cross-sectional design precluded deducing the temporal order of the onset of metabolic syndrome and the elevation of CAVI
Potential selection bias due to targeting patients visiting the health promotion center of a general hospital
Lack of information on confounding factors such as smoking, drinking, exercise, and family history
Cross-sectional design prevented determination of the temporal order between metabolic syndrome onset and CAVI elevation
Potential selection bias as subjects were recruited from a general hospital health promotion center
Lack of data on smoking, alcohol consumption, exercise, and family history

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Implication

Metabolic syndrome was associated with higher CAVI; hypothesis-generating and should not yet change practice.

Abstract

AIM: Metabolic syndrome is characterized by a cluster of atherosclerotic cardiovascular risk factors. The cardioankle vascular index (CAVI) reflects arterial stiffness and may be used as an indicator of atherosclerotic cardiovascular disease. In this study, we investigated the association of CAVI with metabolic syndrome. METHODS: A total of 1,144 adults were included in this study. We measured CAVIs and examined blood samples to identify metabolic syndrome according to WHO Asia Pacific criteria and NCEP-ATPIII criteria. AST, ALT, r-GTP, BUN, creatinine, high sensitivity C-reactive protein, and uric acid were also measured. RESULTS: CAVI values were significantly higher in subjects with metabolic syndrome than those without metabolic syndrome and increased according to the number of metabolic syndrome components present. Subjects with high fasting blood sugar levels or high blood pressure showed high CAVI values. Multiple regression analysis showed that age, sex, diastolic blood pressure, and uric acid were independent predictors of CAVI. CONCLUSION: Subjects with metabolic syndrome had high CAVIs, which indicated arterial stiffness, and were closely associated with an increase in the number of metabolic risk factors. The individual risk factors for metabolic syndrome have the synergistic effect of elevating arterial stiffness in asymptomatic Korean population.

Discussion

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Cite This Study

Nam et al. (2015) conducted a cross-sectional in Metabolic syndrome in an asymptomatic Korean population (n=1,144). Metabolic syndrome (NCEP-ATPIII and WHO Asia Pacific criteria) vs. Subjects without metabolic syndrome was evaluated on Cardioankle vascular index (CAVI) (β = 0.143, p=0.04). Metabolic syndrome was associated with higher cardioankle vascular index values compared to no metabolic syndrome.

synapsesocial.com/papers/6a71b7b675498292b70b1adb https://doi.org/10.1155/2015/328585

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Association of Metabolic Syndrome with the Cardioankle Vascular Index in Asymptomatic Korean Population

Study Design

Structured PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Association of Metabolic Syndrome with the Cardioankle Vascular Index in Asymptomatic Korean Population

Study Design

Structured PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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